Oxygen Free Radical Impairment of Nitric Oxide Activity Noradrenergic Vascular Hyper-Responsiveness in Human Hypertension Is Dependent on
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چکیده
Giuseppe Lembo, Carmine Vecchione, Raffaele Izzo, Luigi Fratta, Dario Fontana, Gennaro Oxygen Free Radical Impairment of Nitric Oxide Activity Noradrenergic Vascular Hyper-Responsiveness in Human Hypertension Is Dependent on Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.102.5.552 2000;102:552-557 Circulation. http://circ.ahajournals.org/content/102/5/552 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity.
BACKGROUND Noradrenergic vascular hyper-responsiveness is a hallmark of essential hypertension. To evaluate whether nitric oxide plays a role in the enhanced vascular response to norepinephrine in hypertension, we examined 32 hypertensives and 28 normotensives who were distributed in 3 experimental series. METHODS AND RESULTS In the first series, we measured the forearm blood flow (FBF) respo...
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